Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
نویسندگان
چکیده
منابع مشابه
Binding and disruption of phospholipid bilayers by supramolecular RNA complexes.
In an RNA world, RNAs would have regulated traffic through normally impermeable bilayer membranes. Using selection-amplification we previously found RNAs that bind stably and increase the ionic conductance of phospholipid membranes at high Mg(2+) and Ca(2+) concentrations. Now selection in reduced divalents yields RNAs that bind phosphatidylcholine liposomes under conditions closer to physiolog...
متن کاملA journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy
This review summarizes part of the author's research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially molecular tweezers. Although designed to complex DNA, these hosts proved more applicable to the field of host-guest chemistry. This early experience and interest in intercalation ultimately led to the...
متن کاملMolecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism.
In type-2 diabetes (T2D), islet amyloid polypeptide (IAPP) self-associates into toxic assemblies causing islet β-cell death. Therefore, preventing IAPP toxicity is a promising therapeutic strategy for T2D. The molecular tweezer CLR01 is a supramolecular tool for selective complexation of K residues in (poly)peptides. Surprisingly, it inhibits IAPP aggregation at substoichiometric concentrations...
متن کاملMetal-coordination-driven mixed ligand binding in supramolecular bisporphyrin tweezers.
Mg(II)bisporphyrin has been used as an efficient host for the selective binding of guest ligands. In the presence of heterogeneous guest pairs, 2-aminopyrimidine/pyrazine and 2-aminopyrimidine/1,4-dioxane, 2-aminopyrimidine is bound selectively inside the bisporphyrin cavity whereas pyrazine/1,4-dioxane is bound outside to produce 1D mixed ligand polymers. UV-vis, (1)H NMR spectra and X-ray str...
متن کاملModulating Molecular Properties by Supramolecular Interactions
Supramolecular interaction is rapidly emerging as the method of choice for tuning molecular properties to meet desired applications like drug delivery vehicles, sensors, designing molecular architectures, catalysis chambers, biomimetic systems and so on. We have successfully demonstrated the modulation of electron and proton transfer reactions, acidbase characteristics and photophysical propert...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2020
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.0c06400